Assessing pain in paralyzed critically ill patients receiving neuromuscular blocking agents: A monocenter prospective cohort
Authors' conclusion
ANI proves the most discriminant parameter for pain detection in both paralyzed and non-paralyzed sedated ICU patients. Its significant and clinically relevant decrease during tracheal suctioning remains unaltered by NMBA use.
Study context
- Population
- Consecutive Intensive-Care-Units (ICU) patients requiring continuous cisatracurium infusionanalysed
- Participants
- 20 patients
- Exposure
- Paralysis vs Recovery
- Outcome
- Discriminant validity of 5 pain-related parameters (values before/during/after the nociceptive procedure)
Methodological detailsmonocentre, consecutive patients
- Monocentre
- Consecutive patients
Main finding
As reported in the abstract
Discriminant validity
- ANI, BIS and HR changed significantly during the nociceptive procedure in both paralysis and recovery; Behavioural-Pain-Scale (BPS) changed only post-recovery
- ANI highest discriminant validity; paralyzed: ANI at rest 71 [48-89] to 41 [25-72] during tracheal suctioning
- Non-paralyzed: ANI at rest 71 [53-85] to 40 [31-52] during tracheal suctioning
Observational data: associations, not effects.
Secondary outcomes
Reliability (effect of paralysis)
- ANI and HR unaffected by paralysis, unlike BIS and BPS
- Mixed-effect model
Original publication
Assessing pain in paralyzed critically ill patients receiving neuromuscular blocking agents: A monocenter prospective cohort. Anaesth Crit Care Pain Med. Published 6 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →