Assessing the changes in outcome measurements in randomized controlled trials of regional anesthesia interventions: a registry-publication comparison study
Authors' conclusion
In this sample of 74 RA trials, differences between the earliest and most recent registered outcome fields were common, including changes involving primary outcomes. For most of these trials, the most recently entered substantive modification occurred after primary completion or publication and was not explicitly explained in the associated publication.
Study context
- Population
- Interventional regional anesthesia (RA) trials in adults registered on ClinicalTrials.gov, initiated January 2017–December 2024, with posted tabular results and a linked peer-reviewed publicationeligible trials
- Participants
- 74 trials
- Outcome
- Outcome changes between earliest and most recent registry versions
Methodological detailsregistry-based, registry-publication comparison
- Registry-based
- Registry-publication comparison
Main finding
As reported in the abstract
- Trials with ≥1 substantive outcome change between registry versions
- 91.9%
- Most recent substantive modification after primary completion (trials with substantive modifications)
- 47.1%
- Most recent substantive modification after publication (trials with substantive modifications)
- 51.5%
- Modifications disclosed
- 0
- Trials with high-impact modifications
- 37.8%
Observational data: associations, not effects.
Original publication
Assessing the changes in outcome measurements in randomized controlled trials of regional anesthesia interventions: a registry-publication comparison study. Reg Anesth Pain Med. Published 29 September 2026. doi:10.
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