Assessment of Tissue Perfusion Pressure in Patients With Septic Shock: Beyond Mean Arterial Pressure
Authors' conclusion
The relationship between arterial pressure and outcomes in septic shock is complex and heterogeneous.
Study context
- Population
- Patients with septic shock
- Outcome
- Assessment of tissue perfusion pressure (TPP) beyond MAP
Methodological detailsliterature search of PubMed and MEDLINE, Included English-language systematic reviews, narrative reviews, meta-analyses, RCTs and observational studies
- Literature search of PubMed and MEDLINE
- Included English-language systematic reviews, narrative reviews, meta-analyses, RCTs and observational studies
Main finding
As reported in the abstract
- Relationship between arterial pressure and outcomes in septic shock is complex and heterogeneous
- Focusing on tissue perfusion pressure (TPP), the vascular waterfall and individual treatment effects enables a more personalized approach focused on perfusion rather than pressure alone
- Persistent hypoperfusion despite adequate macrocirculatory targets marks when microcirculatory assessment becomes essential to guide therapy and avoid potentially harmful escalation of fluids or vasopressors
- Bedside SBP, mean arterial pressure (MAP), diastolic arterial pressure, critical closing pressure (Pcc) and mean systemic filling pressure (Pmsf) offer practical tools for monitoring and tailoring treatment
Original publication
Assessment of Tissue Perfusion Pressure in Patients With Septic Shock: Beyond Mean Arterial Pressure. Crit Care Med. Published 23 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →