ICU sedation, delirium & recovery
Association of active mobilisation variables with adverse events and mortality in patients requiring mechanical ventilation in the intensive care unit: a systematic review and meta-analysis
Pooled result · Adverse eventsResult — go to the resultRelative risk 1.09 95% CI 0.69–1.74Authors' conclusion
Implementation of mobilisation in the ICU was associated with a less than 3% chance of an adverse event occurring and was not found to increase adverse events or mortality overall, providing reassurance for clinicians about the safety of performing this intervention.
Study context
- Population
- Critically ill adults during or after a period of mechanical ventilation in an acute intensive care unit (ICU) setting
- Participants
- 7,004 adults · 67 RCTs
- Comparison
- Active mobilisation vs usual care
- Outcome
- Number of adverse events during implementation of mobilisation
Methodological detailsfrequentist and Bayesian analyses, random-effects modelling
- Frequentist and Bayesian analyses
- Random-effects modelling
Pooled result
Adverse events
Relative risk
1.09
95% CI 0.69–1.74
P = 0.71
Mobilisation vs Usual care
RR 1.09 (95% CI 0.69–1.74); P = 0.71
As reported in the abstract
- Adverse event occurrence rate (693 events in 23 395 intervention sessions; 25 studies)
- 2.96%
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| MortalityI2 0%; n=6218, 58 studies; moderate certainty | 0.98 (0.87–1.12) | P = 0.81 | |
| 0.512Relative risk (log scale) |
Subgroups (duration, timing, ventilation status, admission diagnosis)
- Subgroup analyses did not clearly identify any specific variable of mobilisation that increased harm; hypothesis generating only
Safety
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Adverse eventsVery low certainty | 1.09 (0.69–1.74) | P = 0.71 | |
| 0.512Relative risk (log scale) |
- Adverse events — Adverse event occurrence rate per intervention session
- 2.96%
Original publication
Association of active mobilisation variables with adverse events and mortality in patients requiring mechanical ventilation in the intensive care unit: a systematic review and meta-analysis. Lancet Respir Med. Published 18 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →