ICU sedation, delirium & recovery
Dose–response relationship of early out-of-bed mobilization with functional decline and adverse events in patients after cardiovascular surgery requiring prolonged intensive care: a retrospective cohort study
Main findingResult — go to the resultOdds ratio 2.03 95% CI 1.19–3.45Authors' conclusion
Lower mobilization doses were associated with functional decline, while higher doses were not associated with increased adverse events.
Study context
- Population
- Patients after cardiovascular surgery requiring ≥ 3 days of postoperative ICU care196 per group after matching
- Participants
- 610 patients
- Exposure
- Low-dose vs high-dose early out-of-bed mobilization
- Low-dosen = 196
- High-dosen = 196reference
- Outcome
- Postoperative functional decline (≥ 5-point decrease in Barthel Index vs baseline)
- Follow-up
- Discharge
Methodological detailspropensity score matching (1:1), single cardiovascular ICU
- Propensity score matching (1:1)
- Single cardiovascular ICU
Main finding
As reported in the abstract
Odds ratio
2.03
95% CI 1.19–3.45
P = 0.009
By group
Low-dose vs High-dose
OR 2.03 (95% CI 1.19–3.45); P = 0.009
Observational data: associations, not effects.
Further findings
Dose-response relationship (restricted cubic spline)
- Nonlinear dose-response relationship between mobilization dose and functional outcomes
Safety
Adverse events during mobilization
- Adverse events infrequent overall
- 1.2%
- No significant difference between groups: incidence rate ratio
- 0.88
- 95% CI
- 0.43-1.74
- P
- P = 0.70
- Propensity-matched cohort
Original publication
Dose–response relationship of early out-of-bed mobilization with functional decline and adverse events in patients after cardiovascular surgery requiring prolonged intensive care: a retrospective cohort study. J Intensive Care. Published 4 June 2026. doi:10.
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