ICU sedation, delirium & recovery
Impact of mobilization dose on outcome of critically ill patients receiving mechanical ventilation—a target trial emulation using data from the TEAM trial
Authors' conclusion
Prolonged mobilization when only lower IMS levels could be achieved was associated with increased 28-day mortality.
Study context
- Population
- Adults in the ICU undergoing invasive mechanical ventilation in the TEAM trial
- Participants
- 741 adults
- Comparison
- Simulated mobilization strategies vs natural course
- Primary endpoint
- Mortality
- Follow-up
- 28 days
Methodological detailstarget trial emulation, per-protocol effect, g-formula, post hoc
- Target trial emulation
- Per-protocol effect
- G-formula
- Post hoc
Primary result
As reported in the abstract
28-day mortality
Each group vs natural courseRelative risk (95% CI)
Mobilization ≤20 minutes, mobility scale 2prolonged mobilization time worse when lower mobility levels achieved
1.33(1.10–1.63)
Mobilization ≤20 minutes, IMS 4with IMS >4 achieved, prolonged duration did not increase mortality
1.13(0.96–1.46)
Original publication
Impact of mobilization dose on outcome of critically ill patients receiving mechanical ventilation—a target trial emulation using data from the TEAM trial. Am J Respir Crit Care Med. Published 23 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →