Association between anemia and trauma-related severe acute kidney injury in trauma patients at risk of major bleeding: A post-hoc analysis of the RESTRIC trial
Primary result · Trauma-related severe AKIResult — go to the resultAdjusted odds ratio 3.9 95 % CI 1.2–12.9Authors' conclusion
Anemia at ED admission might be associated with trauma-related AKI in trauma patients at risk of major bleeding.
Study context
- Population
- Trauma patients at risk of major bleeding (RESTRIC trial), excluding chronic hemodialysisfinal study population
- Participants
- 417 patients
- Comparison
- Anemia vs no anemia at emergency department (ED) admission
- Anemian = 63
- Primary endpoint
- Trauma-related severe AKI (KDIGO Stage 3)
- Follow-up
- Within 7 days of admission
Methodological detailspost-hoc analysis, retrospective, cluster-randomized, crossover, multicenter, propensity score-adjusted multivariate logistic regression
- Post-hoc analysis
- Retrospective
- Cluster-randomized
- Crossover
- Multicenter
- Propensity score-adjusted multivariate logistic regression
Primary result
Trauma-related severe AKI
Adjusted odds ratio
3.9
95 % CI 1.2–12.9
P = 0.029
Anemia vs No anemia
aOR 3.9 (95 % CI 1.2–12.9); P = 0.029
As reported in the abstract
- Trauma-related severe acute kidney injury (AKI), all patients
- 15 (3.6 %)
Original publication
Association between anemia and trauma-related severe acute kidney injury in trauma patients at risk of major bleeding: A post-hoc analysis of the RESTRIC trial. J Crit Care. Published 24 November 2025. doi:10.
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