The Efficacy of Low-Titer Group O Whole Blood Compared With Component Therapy in Civilian Trauma Patients: A Meta-Analysis
Authors' conclusion
These data suggest hemostatic resuscitation with LTOWB compared with CT improves early and late survival outcomes in bleeding civilian trauma patients.
Study context
- Population
- Injured civilian adults and children with bleeding trauma
- Participants
- 58,717 adults · 24 studies
- Comparison
- Low-titer group O whole blood vs component therapy
- LTOWBn = 5,164
- Outcome
- Early (24-hour) and late (combined 28-day, 30-day and in-hospital) mortality
Methodological detailsrandom-effects models, MOOSE guidelines
- Random-effects models
- MOOSE guidelines
Pooled result
As reported in the abstract
LTOWB vs CTRelative risk (95% CI)
24-hour survival; 14 studies
1.07(1.03–1.12)
Late survival; 22 studies
1.05(1.01–1.09)
Further pooled results
Age
Small study bias and risk of bias
- No evidence of small study bias; all studies graded moderate level of bias
Original publication
The Efficacy of Low-Titer Group O Whole Blood Compared With Component Therapy in Civilian Trauma Patients: A Meta-Analysis. Crit Care Med. Published 14 March 2024. doi:10.
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