Low Titer Group O Whole Blood In Injured Children Requiring Massive Transfusion
Main finding · 28-day survivalResult — go to the resultAdjusted odds ratio 0.41 event not clearly statedAuthors' conclusion
Administration of LTOWB during the hemostatic resuscitation of injured children requiring massive transfusion was independently associated with improved 72-hour and 28-day survival.
Study context
- Population
- Injured children aged 1 to 17 years receiving >40 mL/kg of LTOWB and/or conventional components over 24 hours after admission (massive transfusion)analysed
- Participants
- 80 children
- Exposure
- LTOWB as part of hemostatic resuscitation vs component therapy
- LTOWBn = 27
- Outcome
- 28-day survival
- Follow-up
- 28 days
Methodological detailssingle-centre, urban academic pediatric Level 1 trauma center
- Single-centre
- Urban academic pediatric Level 1 trauma center
Main finding
As reported in the abstract
Adjusted odds ratio
0.41
event not clearly stated
P = 0.02
Observational data: associations, not effects.
Further findings
| Outcome | aOR | P value |
|---|---|---|
| 72-hour survival · significantly improved survival with LTOWB; adjusted | 0.23 | P = 0.009 |
| 6-hour survival · not statistically significant | 0.51 | P = 0.30 |
Hospital LOS, ICU LOS, ventilator days (28-day survivors)
- Reduced in LTOWB vs CT
Original publication
Low Titer Group O Whole Blood In Injured Children Requiring Massive Transfusion. Ann Surg. Published 8 October 2021. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →