Association Between Blood Donor Demographics and Post-injury Multiple Organ Failure after Polytrauma
Authors' conclusion
Blood components donor sex, but not age, may be an important factor associated with post-injury MOF.
Study context
- Population
- Critically injured transfused polytrauma patients4,379 donated units
- Participants
- 229 participants
- Exposure
- Blood donor demographics and recipient post-injury multiple organ failure (MOF)
- Outcome
- Post-injury multiple organ failure (MOF)
Methodological detailslog-linear analysis accounting for correlated data, prospective MOF database
- Log-linear analysis accounting for correlated data
- Prospective MOF database
Main finding
As reported in the abstract
MOF by donor sex and age
- Donor-recipient sex mismatched RBC transfusions more likely associated with MOF
- P = 0.0012
- FFP recipients more likely to experience MOF with male (vs female) component
- P = 0.0014
- Cryoprecipitate recipients more likely to experience MOF with male (vs female) component
- <0.0001
Observational data: associations, not effects.
Original publication
Association Between Blood Donor Demographics and Post-injury Multiple Organ Failure after Polytrauma. Ann Surg. Published 22 January 2021. doi:10.
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