Integrated clustering of multiple immune marker trajectories reveals different immunotypes in severely injured patients
Authors' conclusion
Our study suggest that the immune system of critically ill patients can be characterized by two distinct longitudinal immunotypes, one of which included patients with a persistently dysregulated and impaired immune response.
Study context
- Population
- Severely injured patients admitted to ICU
- Participants
- 339 participants
- Outcome
- Immunotypes from immune marker trajectories (first week after ICU admission)
Main finding
As reported in the abstract
- Both marker sets (common biomarkers; whole blood immune-related mRNA) revealed two immunotypes
- One immunotype associated with worse outcomes: increased risk of hospital-acquired infection and mortality, prolonged hospital stays
- This immunotype showed signs of both hyperinflammation and immunosuppression, persisting over time
Observational data: associations, not effects.
Original publication
Integrated clustering of multiple immune marker trajectories reveals different immunotypes in severely injured patients. Crit Care. Published 15 July 2024. doi:10.
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