Perioperative medicine & outcomes
The association between elevated preoperative red cell distribution width and worsening kidney function after noncardiac operation. A propensity score and competing risk weighted retrospective cohort study
Authors' conclusion
Elevated preoperative RDW was associated with long-term worsening of eGFR category after operation.
Study context
- Population
- Adults ≥18 yr undergoing noncardiac surgery at Landspitali-The National University Hospital of Iceland, 2005–2018
- Participants
- 63,056 operations
- Exposure
- Elevated preoperative RDW vs propensity score-matched controls
- Outcome
- Time to worsening of ≥1 estimated glomerular filtration rate (eGFR) category sustained for 3 months
Methodological detailspropensity score-matched, Fine-Gray competing risk regression (death as competing event), single-centre
- Propensity score-matched
- Fine-Gray competing risk regression (death as competing event)
- Single-centre
Main finding
As reported in the abstract
Long-term eGFR worsening
Each group vs RDW ≤13.3%Hazard ratio (95% CI)
14.0-14.7%
1.23(1.13–1.35)
14.7-15.8%
1.20(1.07–1.34)
>15.8%
1.16(1.00–1.34)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Values | P value |
|---|---|---|
| Readmission (RDW 14.0-14.7% subgroup)14.0-14.7% vs RDW ≤13.3% | 14.0-14.7% 9.8% · RDW ≤13.3% 8.5% | P = 0.01 |
| Readmission (RDW 14.7-15.8% subgroup)14.7-15.8% vs RDW ≤13.3% | 14.7-15.8% 12.2% · RDW ≤13.3% 10.1% | P = 0.001 |
| Readmission (RDW >15.8% subgroup)>15.8% vs RDW ≤13.3% | >15.8% 14.9% · RDW ≤13.3% 11.4% | P < 0.001 |
AKI
- No difference in AKI
Original publication
The association between elevated preoperative red cell distribution width and worsening kidney function after noncardiac operation. A propensity score and competing risk weighted retrospective cohort study. BJA Open. Published 27 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →