Perioperative medicine & outcomes
Association between general anesthesia combined with peripheral nerve blocks versus neuraxial anesthesia without nerve blocks for high-risk isolated distal deep venous thrombosis in patients undergoing knee arthroplasty: a historical cohort study
An erratum to this article was published (Can J Anaesth, Sep 2025 ↗)
Main finding · High-risk IDDVTResult — go to the resultOdds ratio 0.50 95% CI 0.31–0.81Authors' conclusion
Compared with neuraxial anesthesia without peripheral nerve blocks, general anesthesia combined with peripheral nerve blocks in patients undergoing knee arthroplasty was associated with a reduced incidence of high-risk IDDVT in our retrospective study.
Study context
- Population
- Adults who underwent knee arthroplasty, Shenzhen Second People's Hospital, 1 September 2019 to 31 August 2021848 screened, 330 excluded
- Participants
- 518 adults
- Exposure
- GA + nerve blocks vs Neuraxial anesthesia
- GA + nerve blocksn = 267
- Neuraxial anesthesian = 251reference
- Outcome
- Incidence of high-risk isolated distal deep venous thrombosis (IDDVT)
Methodological detailshistorical cohort, single-centre, inverse probability weighting according to the propensity score, multivariable regression
- Historical cohort
- Single-centre
- Inverse probability weighting according to the propensity score
- Multivariable regression
Main finding
High-risk IDDVT
Odds ratio
0.50
95% CI 0.31–0.81
P = 0.005
GA + nerve blocks vs Neuraxial anesthesia
OR 0.50 (95% CI 0.31–0.81); P = 0.005
As reported in the abstract
- Patients who developed high-risk isolated distal deep venous thrombosis (IDDVT) (total)
- 99
Observational data: associations, not effects.
Further findings
Multiple sensitivity analyses
- Results similar between the two cohorts
E-value analysis
- Suggested robustness to unmeasured confounding
Original publication
Association between general anesthesia combined with peripheral nerve blocks versus neuraxial anesthesia without nerve blocks for high-risk isolated distal deep venous thrombosis in patients undergoing knee arthroplasty: a historical cohort study. Can J Anaesth. Published 28 May 2025. doi:10.
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