Perioperative medicine & outcomes
Association between hydroxyethyl starch 130/0.4 administration during noncardiac surgery and postoperative acute kidney injury: A propensity score-matched analysis of a large cohort in China
Main findingResult — go to the resultOdds ratio 0.90 CI 0.74–1.08Authors' conclusion
Hydroxyethyl starch 130/0.4 use was not significantly associated with a greater incidence of postoperative acute kidney injury compared to receiving crystalloid solutions only.
Study context
- Population
- Chinese adults undergoing noncardiac surgery, one tertiary care hospital, 2013–2022
- Participants
- 51,926 adults · 11,725 matched pairs
- Exposure
- Hydroxyethyl starch vs Crystalloid
- Outcome
- Incidence of AKI
Methodological detailspropensity-score matched, single-centre
- Propensity-score matched
- Single-centre
Main finding
As reported in the abstract
Odds ratio
0.90
CI 0.74–1.08
P = 0.25
By group
Hydroxyethyl starch vs Crystalloid
OR 0.90 (CI 0.74–1.08); P = 0.25
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| AKI stagePropensity-matched cohort | 0.90 (0.75–1.08) | P = 0.26 | |
| 0.512Odds ratio (log scale) |
Outcomes in patients at high risk of renal injury (subgroup)
- Hydroxyethyl starch use not associated with worse outcomes
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between hydroxyethyl starch 130/0.4 administration during noncardiac surgery and postoperative acute kidney injury: A propensity score-matched analysis of a large cohort in China. J Clin Anesth. Published 8 May 2024. doi:10.
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