Perioperative medicine & outcomes
Alterations in the gut microbiome and metabolome in elderly patients with postoperative delirium: A prospective nested case-control study
Authors' conclusion
This study identified four preoperative bacterial genera and four postoperative plasma metabolites associated with an increased risk of POD in elderly orthopedic patients
Study context
- Population
- Elderly patients undergoing elective orthopedic surgery, Chinese tertiary hospitalfollowed up
- Participants
- 234 patients
- Comparison
- Postoperative delirium (POD) vs Control
- PODn = 39
- Controln = 39reference
- Outcome
- Gut microbiota and metabolites associated with POD
Methodological details1:1 propensity score matching
- 1:1 propensity score matching
Main finding
As reported in the abstract
Microbiota- and metabolite-derived indicators predicted POD: AUC
0.8413
95% CI 0.7393–0.9434
Observational data: associations, not effects.
Original publication
Alterations in the gut microbiome and metabolome in elderly patients with postoperative delirium: A prospective nested case-control study. J Clin Anesth. Published 13 April 2025. doi:10.
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