Cardiothoracic & vascular anesthesia
Protein Alterations in Patients with Delirium after Cardiac Surgery: An Exploratory Case–Control Substudy of the VISION Cardiac Surgery Biobank
Authors' conclusion
The study identified 26 biomarkers significantly associated with delirium; all are novel except for interleukin-8.
Study context
- Population
- Cardiac surgery patients, VISION Cardiac Surgery Biobank
- Participants
- 30 vs 30
- Comparison
- Delirium cases vs matched controls
- Casesn = 30
- Controlsn = 30reference
- Primary endpoint
- Blood protein alterations (Olink Explore 3K; false discovery rate-adjusted P<0.05)
- Follow-up
- Postoperative day 3
Methodological detailsexploratory, matched, substudy of the VISION Cardiac Surgery Biobank, convenience sample
- Exploratory
- Matched
- Substudy of the VISION Cardiac Surgery Biobank
- Convenience sample
Primary result
As reported in the abstract
Serum proteins associated with delirium
- Proteins significantly associated with delirium status, all elevated in cases vs controls (of 2,865)
- 26 (0.9%)
- FKBP1B
- Padj = 0.003
- C2CD2L
- Padj = 0.004
- RAB6B
- Padj = 0.004
Further findings
| Outcome | Mean difference | P value |
|---|---|---|
| Interleukin-8 (CXCL8) | 2.36 | P = 3.6 × 10- 4 |
Pathway analysis
- Calcium-release channel activity
- Padj = 0.02
- GTP-binding
- Padj = 0.005
Original publication
Protein Alterations in Patients with Delirium after Cardiac Surgery: An Exploratory Case–Control Substudy of the VISION Cardiac Surgery Biobank. Anesthesiology. Published 9 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →