Cardiothoracic & vascular anesthesia
Cardiac surgery with valve replacement temporarily disrupts the hippocampal memory network
Authors' conclusion
Valve replacement surgery temporarily disrupts the hippocampal memory network with transient associated memory decline.
Study context
- Population
- Patients with valvular heart disease undergoing valve replacement surgery35 patients and 29 controls analysed
- Participants
- 43 vs 30
- Exposure
- Patients undergoing heart valve replacement surgery vs healthy controls
- Surgeryn = 43
- Healthy controlsn = 30reference
- Outcome
- Cognition and FC of the hippocampal memory network
- Follow-up
- Before surgery, POD 7 and 30
Methodological detailsage- and sex-matched healthy controls, resting-state functional MRI, hippocampal seed-based functional connectivity (FC) analysis
- Age- and sex-matched healthy controls
- Resting-state functional MRI
- Hippocampal seed-based FC analysis
Main finding
As reported in the abstract
Hippocampal FC, memory and inflammation
- Before surgery: increased FC in bilateral precuneus and middle cingulate and paracingulate gyri in Surgery vs Healthy controls
- POD 7: impaired memory, increased plasma proinflammatory cytokines and decreased hippocampal FC in Surgery
- POD 30: FC abnormalities restored to level comparable with Healthy controls
- High systemic inflammation significantly associated with worse memory and lower FC in the hippocampal memory network
Observational data: associations, not effects.
Original publication
Cardiac surgery with valve replacement temporarily disrupts the hippocampal memory network. Br J Anaesth. Published 19 December 2024. doi:10.
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