Cardiothoracic & vascular anesthesia
Efficacy and safety of gastrodin in preventing postoperative delirium following cardiac surgery: a randomized placebo controlled clinical trial
Primary result · Postoperative deliriumResult — go to the resultRelative risk 0.54 95% CI 0.32–0.93Authors' conclusion
Gastrodin infusion significantly reduced postoperative delirium and improved discharge outcomes in patients undergoing CABG
Study context
- Population
- Patients aged 18–75 scheduled for coronary artery bypass grafting (CABG), with or without valve replacement155 analysed
- Participants
- 160 patients
- Comparison
- Gastrodin vs Placebo
- Gastrodinn = 77
- Placebon = 78reference
- Primary endpoint
- Co-primary: incidences of delirium and postoperative cognitive dysfunction (POCD)
- Follow-up
- ICU admission until POD 7 and at 1 and 3 months postoperatively
Methodological detailsdouble-blind, placebo-controlled
- Double-blind
- Placebo-controlled
Primary result
Postoperative delirium
Relative risk
0.54
95% CI 0.32–0.93
P = 0.022
By group
Gastrodin vs Placebo
RR 0.54 (95% CI 0.32–0.93); P = 0.022
As reported in the abstract
Further findings
In-hospital POCD (co-primary)
| Outcome | Subhazard ratio (95% CI) | P value | |
|---|---|---|---|
| Hospital discharge | 1.20 (1.00–1.84) | P = 0.049 | |
| 0.512Subhazard ratio (log scale) |
Safety
Adverse events
Adverse events
- None drug-related
Original publication
Efficacy and safety of gastrodin in preventing postoperative delirium following cardiac surgery: a randomized placebo controlled clinical trial. Crit Care. Published 11 March 2025. doi:10.
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