Cardiothoracic & vascular anesthesia
Impact of Restrictive Versus Liberal Oxygenation on Pulmonary Decline After Cardiac Surgery: A Substudy of the GLORIOUS Randomized Clinical Trial
Authors' conclusion
While pulmonary function exhibited a mild-to-moderate decline 3 months after cardiac surgery, a restrictive (FiO2 50%) oxygenation strategy during CPB did not attenuate this decline compared with a liberal (FiO2 100%) strategy.
Study context
- Population
- Adults undergoing nonemergent coronary artery bypass grafting (CABG) and/or surgical aortic valve replacement, single tertiary center
- Participants
- 878 adults
- Comparison
- Restrictive vs Liberal
Methodological detailspredefined, exploratory substudy, single-centre
- Predefined
- Exploratory substudy
- Single-centre
Primary result
As reported in the abstract
Between-group difference in pulmonary function decline · 3 months
- No significant between-group differences in decline (all p > 0.3), including in subgroup analyses
Further findings
Pulmonary function decline, overall study population · 3 months
- Median FEV₁ (% predicted) decline, percentage points
- 8.3 (95% CI 6.6 to 8.3; p< 0.001)
- FVC (% predicted) decline, percentage points
- 6.1 (95% CI 5.2 to 7.0; p< 0.001)
- FEV₁/FVC decline, percentage points
- 1.6 (95% CI 1.0 to 2.1; p< 0.001)
- Diffusion capacity of carbon monoxide (% predicted corrected) decline, percentage points
- 7.7 (95% CI 6.2 to 9.1; p< 0.001)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Impact of Restrictive Versus Liberal Oxygenation on Pulmonary Decline After Cardiac Surgery: A Substudy of the GLORIOUS Randomized Clinical Trial. J Cardiothorac Vasc Anesth. Published 14 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →