Perioperative medicine & outcomes
Association between serum chemokines levels and delayed neurocognitive recovery after non-cardiac surgery in elderly patients: a nested case–control study
Authors' conclusion
Serum levels of CCL 5 and CCL 11 significantly decreased in elderly patients with dNCR following non-cardiac surgery, which may contribute to the identification of patients at high risk for dNCR.
Study context
- Population
- Elderly patients undergoing elective major non-cardiac surgery
- Participants
- 144 patients · 21 matched pairs
- Comparison
- Serum chemokines in matched delayed neurocognitive recovery (dNCR) vs non-dNCR
- dNCRn = 21
- non-dNCRn = 21reference
- Outcome
- Serum levels of CCL2, CCL5, CCL11 and CXCL8 (before anaesthesia and 1 h after its cessation) in matched dNCR vs non-dNCR
Methodological detailsretrospective, matched (1 control per case)
- Retrospective
- Matched (1 control per case)
Main finding
As reported in the abstract
Serum chemokines, dNCR vs non-dNCR
- No significant differences in CCL2 or CXCL8 between matched groups
- dNCR vs non-dNCR: P = 0.039
- dNCR vs non-dNCR: P = 0.030
- dNCR vs non-dNCR: P = 0.046
- dNCR vs non-dNCR: P = 0.046
- dNCR vs non-dNCR: P = 0.005
- Matched cohort
Observational data: associations, not effects.
Further findings
Incidence of dNCR · 7 days post-surgery
- dNCR observed
- 31.25% (45 of 144)
Original publication
Association between serum chemokines levels and delayed neurocognitive recovery after non-cardiac surgery in elderly patients: a nested case–control study. Perioper Med (Lond). Published 12 April 2025. doi:10.
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