Respiratory failure & ventilation
Association between lactate-to-albumin ratio and short-time mortality in patients with acute respiratory distress syndrome
Main finding · 28-day mortalityResult — go to the resultHazard ratio 1.11 95 % CI 1.06–1.16Authors' conclusion
We confirmed that there was a positive correlation between LAR and 28-day mortality.
Study context
- Population
- Patients with acute respiratory distress syndrome (ARDS)
- Participants
- 769 patients
- Exposure
- High vs low lactate-to-albumin ratio
- Outcome
- 28-day all-cause mortality
- Follow-up
- 28 days
Methodological detailsMIMIC-IV (v2.2) database
- MIMIC-IV (v2.2) database
Main finding
28-day mortality
Hazard ratio
1.11
95 % CI 1.06–1.16
P < 0.001
LAR
HR 1.11 (95 % CI 1.06–1.16); P < 0.001
As reported in the abstract
- 28-day mortality, overall cohort
- 38 %
Observational data: associations, not effects.
Further findings
AUC, %
| Outcome | LAR | Lactate | Albumin | SAPSII | P value |
|---|---|---|---|---|---|
| Discrimination for 28-day mortality (ROC AUC)LAR vs Lactate · LAR significantly higher | 70.34 (95% CI 66.53 % - 74.15 %) | 68.00 | 63.17 | 73.44 (95% CI 69.84 % - 77.04 %) | P = 0.0007 |
| Discrimination for 28-day mortality (ROC AUC)LAR vs Albumin · LAR significantly higher | P = 0.002 | ||||
| Discrimination for 28-day mortality (ROC AUC)LAR vs SAPSII · LAR not inferior to SAPSII | P = 0.21 | ||||
| In-hospital mortalityHigh LAR vs Low LAR · significantly higher with high LAR | P < 0.001 | ||||
| Hospital LOSHigh LAR vs Low LAR | P < 0.001 |
- Hospital LOS: shorter with high lactate-to-albumin ratio (LAR), possibly due to higher in-hospital mortality
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between lactate-to-albumin ratio and short-time mortality in patients with acute respiratory distress syndrome. J Clin Anesth. Published 26 September 2024. doi:10.
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