Perioperative medicine & outcomes
Association Between Naloxone Coprescription Mandates and Postoperative Outcomes
Authors' conclusion
Naloxone coprescription mandates were not associated with a statistically or clinically significant change in emergency department visits or hospital admissions within 30 postoperative days.
Study context
- Population
- Patients undergoing 1 of 50 common procedures (January 1, 2004–June 30, 2019) categorized as high risk for opioid overdose
- Participants
- 429,878 patients
- Exposure
- After vs before implementation of naloxone coprescription mandates
- Outcome
- ED visit or hospital admission
- Follow-up
- 30 postoperative days
Methodological detailsdifference-in-differences, healthcare claims data
- Difference-in-differences
- Healthcare claims data
Main finding
As reported in the abstract
- No significant association between naloxone prescribing mandates and the primary outcomes
Observational data: associations, not effects.
Further findings
| Outcome | After | Before | Estimate | P value | |
|---|---|---|---|---|---|
| Hospital admission · 30 postoperative daysAdjusted for potential confounders | 3.26% | 3.33% | difference change −0.08% (95% CI −0.44% to 0.29%) | P = 0.68 | |
| ED visit · 30 postoperative daysAdjusted for potential confounders | 7.06% | 7.73% | difference −0.67% (95% CI −1.39% to 0.05%) | P = 0.07 | |
| −2−101Difference (linear scale) |
Sensitivity and subgroup analyses (subgroup)
- Results robust to a variety of sensitivity and subgroup analyses
Original publication
Association Between Naloxone Coprescription Mandates and Postoperative Outcomes. Ann Surg. Published 20 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →