ICU sedation, delirium & recovery

Association Between Patients’ Admission to the ICU and Psychological Disorders in Their Families: A Retrospective Matched-Pair Cohort Study

Crit Care MedPublished Retrospective cohort study

Main findingResult — go to the resultAdjusted odds ratio 1.08 95% CI 1.02–1.15

Authors' conclusion

Families of ICU patients, especially spouses, were more likely to seek medical care for psychological disorders associated with PICS-F within 6 months than individuals not exposed to a family member's ICU admission.

Study context

Population
Family members of ICU patients in a Japanese administrative claims database (DeSC Healthcare, 3.44 million insurance subscribers)family members of 27,748 ICU patients
Participants
35,652 vs 142,463
Exposure
ICU patients' families vs Matched individuals
  • ICU patients' familiesn = 35,652
  • Matched individualsn = 142,463reference
Outcome
Prevalence of psychological disorders associated with a PICS-F diagnosis needing medical care at least once
Follow-up
Within 6 months after the ICU admission date
Methodological detailsmatched-pair, administrative claims database
  • Matched-pair
  • Administrative claims database

Main finding

As reported in the abstract

6 months

Adjusted odds ratio

1.08

95% CI 1.02–1.15

By group

ICU patients' families vs Matched individuals
aOR 1.08 (95% CI 1.02–1.15)

Observational data: associations, not effects.

Further findings

Psychological disorders associated with post-intensive care syndrome family (PICS-F) by relationship to ICU patient (subgroup) · 6 months

Spouses: significantly higher prevalence than matched individuals
Parents and children: no significant differences

Original publication

Association Between Patients’ Admission to the ICU and Psychological Disorders in Their Families: A Retrospective Matched-Pair Cohort Study. Crit Care Med. Published 30 July 2025. doi:10.1097/ccm.0000000000006793

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