Pediatric anesthesia & critical care
Association between plasma-free haemoglobin and postoperative acute kidney injury in paediatric cardiac surgery: a prospective observational study
Main finding · Peak PFH concentrationResult — go to the resultOdds ratio 1.00 95% CI 0.99–1.00Authors' conclusion
There was an association between postoperative AKI and CPB time rather than PFH. Perioperative peak PFH concentrations were significantly higher in patients with postoperative AKI after paediatric cardiac surgery requiring CPB.
Study context
- Population
- Children aged <5 yr undergoing cardiac surgery requiring cardiopulmonary bypass (CPB)
- Participants
- 179 children
- Exposure
- Acute kidney injury (AKI) vs no AKI
- AKIn = 74
- Outcome
- Relationship between peak plasma-free haemoglobin (PFH) concentrations and postoperative AKI
- Follow-up
- Up to 3 days after surgery
Methodological detailssingle-centre
- Single-centre
Main finding
Peak PFH concentration
Odds ratio
1.00
95% CI 0.99–1.00
P = 0.268
By group
Peak PFH
OR 1.00 (95% CI 0.99–1.00); P = 0.268
As reported in the abstract
Observational data: associations, not effects.
Further findings
Risk factors for AKI (multivariable)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Age in months | 0.96 (0.94–0.99) | P = 0.007 | |
| CPB duration | 1.02 (1.01–1.02) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Incidence of postoperative AKI · up to 3 days after surgery
- Developed postoperative AKI
- 74 (41%)
Original publication
Association between plasma-free haemoglobin and postoperative acute kidney injury in paediatric cardiac surgery: a prospective observational study. BJA Open. Published 26 October 2024. doi:10.
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