Pediatric anesthesia & critical care
The use of intranasal sufentanil and/or s‐ketamine for treatment of procedural pain in children in an ambulatory setting: A retrospective observational study
Authors' conclusion
Intranasal sufentanil and/or s-ketamine are feasible for the treatment of procedural pain in an ambulatory setting with appropriate per- and post-procedural observations and trained staff.
Study context
- Population
- Children 1 year up till 18 years undergoing painful medical procedures outside the operating room, tertiary care paediatric hospitalmedical procedures, 2004–2014
- Participants
- 2,185 children
- Exposure
- Intranasal sufentanil vs s-ketamine vs free combination
- Outcome
- Frequency of adverse events including serious adverse events, by intervention
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Procedures with at least one adverse event
- Common adverse events: vomiting
- 9%
- Common adverse events: nausea
- 8%
- Common adverse events: dizziness
- 3%
- Serious adverse events in intranasal (IN) S (1 respiratory depression and bronchospasm; 1 seizure in a patient with cerebral palsy), handled immediately, no sequelae
- 2
Observational data: associations, not effects.
Secondary outcomes
Median, μg/kg
| Outcome | IN SK | IN S |
|---|---|---|
| Intranasal sufentanil dose | 0.5 (range 0.2–1.3) | 0.8 (range 0.2–2.7) |
- Intranasal sufentanil dose — Median sufentanil dose lower when combined with s-ketamine
- 38%
- Intranasal sufentanil dose: s-ketamine dose in IN SK 0.5 mg/kg (range 0.2-1.5)
Analgesic effect
- Similar analgesic effect for S and SK
Safety
- Serious adverse events — IN S
- 2 events
Serious adverse events
- Respiratory depression and bronchospasm (1); seizure in cerebral palsy (1); no sequelae
Original publication
The use of intranasal sufentanil and/or s‐ketamine for treatment of procedural pain in children in an ambulatory setting: A retrospective observational study. Acta Anaesthesiol Scand. Published 18 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →