Perioperative medicine & outcomes
Association between pre‐operative sodium‐glucose cotransporter‐2 inhibitor use and postoperative outcomes: a propensity score‐matched analysis of the TriNetX database
Main finding · 30-day all-cause mortalityResult — go to the resultRelative risk 0.61 95% CI 0.55–0.67Authors' conclusion
Our study showed a significantly reduced risk of postoperative mortality and morbidity associated with pre-operative sodium-glucose cotransporter-2 inhibitor use in patients with type 2 diabetes mellitus, including a notably lower rate of diabetic ketoacidosis, contrary to previous concerns.
Study context
- Population
- Patients with type 2 DM undergoing surgery in the US98,118 matched pairs
- Participants
- 98,118 vs 98,118
- Exposure
- Sodium-glucose cotransporter-2 inhibitor vs control
- Sodium-glucose cotransporter-2 inhibitorn = 98,118
- Controln = 98,118reference
- Outcome
- All-cause mortality
- Follow-up
- 30 days
Methodological detailspropensity-score matched, nationwide, TriNetX database
- Propensity-score matched
- Nationwide
- TriNetX database
Main finding
30-day all-cause mortality
Relative risk
0.61
95% CI 0.55–0.67
P < 0.001
SGLT2 inhibitor vs Control
RR 0.61 (95% CI 0.55–0.67); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| MACEPropensity-score matched cohort | 0.89 (0.86–0.91) | P < 0.001 | |
| AKIPropensity-score matched cohort | 0.71 (0.69–0.74) | P < 0.001 | |
| 0.512Relative risk (log scale) |
30-day all-cause mortality by subgroup (subgroup)
- More pronounced mortality reduction in females, patients with obesity or proteinuria, and cardiovascular surgery
Safety
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Diabetic ketoacidosisPropensity-score matched cohort | 0.31 (0.18–0.540) | P < 0.001 | |
| 0.20.5125Relative risk (log scale) |
Original publication
Association between pre‐operative sodium‐glucose cotransporter‐2 inhibitor use and postoperative outcomes: a propensity score‐matched analysis of the TriNetX database. Anaesthesia. Published 14 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →