Perioperative medicine & outcomes
Preoperative Glucagon-like Peptide-1 Receptor Agonists and Postoperative Outcomes: An Observational Analysis
Authors' conclusion
Preoperative GLP-1 RA use was associated with lower short-term postoperative mortality and reduced morbidity compared with metformin and DPP4is, and no increased aspiration risk compared with any other drug class.
Study context
- Population
- Adult surgical patients with type 2 DM having anesthesia, June 1, 2013 to June 1, 2023
- Exposure
- Preoperative GLP-1 RA use vs metformin, sodium-glucose cotransporter 2 inhibitors, or DPP4i
- Outcome
- 14-day postoperative outcomes
- Follow-up
- 14-day
Methodological detailspropensity-score matched 1:1, electronic health record database (TriNetX Research Network)
- Propensity-score matched 1:1
- Electronic health record database (TriNetX Research Network)
Main finding
As reported in the abstract
Relative risk (95% CI)P value
GLP-1 RAs vs Metforminmortality 0.98% vs . 2.20%
0.44(0.31–0.64)
Padj = 0.0002GLP-1 RAs vs SGLT2 inhibitorsMACE 3.86% vs . 5.03%
0.77(0.60–0.98)
Padj = 0.13GLP-1 RAs vs DPP4imortality 1.84% vs . 2.89%
0.63(0.45–0.89)
Padj = 0.04GLP-1 RAs vs DPP4ibacterial pneumonia 0.85% vs . 1.80%
0.47(0.29–0.76)
Padj = 0.02Observational data: associations, not effects.
Original publication
Preoperative Glucagon-like Peptide-1 Receptor Agonists and Postoperative Outcomes: An Observational Analysis. Anesthesiology. Published 25 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →