Perioperative medicine & outcomes
Preoperative fasting status and retained gastric contents in patients undergoing endoscopy who are using glucagon-like peptide type 1 receptor agonists: a multicentre retrospective study
Main finding · RGCResult — go to the resultAdjusted odds ratio 0.33 95% CI 0.13–0.81Authors' conclusion
Patients with an active prescription for GLP-1 RA had lower odds of RGC during EGD after more than 15 hr fasting of solids.
Study context
- Population
- Patients actively taking or recently discontinued (within 90 days) a GLP-1 RA undergoing elective esophagogastroduodenoscopy (EGD) at five Henry Ford Health System hospitals, January 2018–December 2023
- Participants
- 337 participants · 5 hospitals
- Exposure
- Solid fasting >15 hr vs ≤15 hr
- Outcome
- Presence of RGC (any small, moderate, or large amount of food or gastric material reported by the endoscopist)
Methodological detailsmulticentre, multivariable logistic regression
- Multicentre
- Multivariable logistic regression
Main finding
RGC
Adjusted odds ratio
0.33
95% CI 0.13–0.81
P = 0.02
>15 hr vs ≤15 hr
aOR 0.33 (95% CI 0.13–0.81); P = 0.02
As reported in the abstract
- Overall prevalence of retained gastric contents (RGC)
- 8.4%
Observational data: associations, not effects.
Further findings
GLP-1 RA suspension <7 days before procedure
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Suspension <7 days | 5.23 (0.67–39.38) | P = 0.12 | |
| 0.050.21520Adjusted odds ratio (log scale) |
Liquid fasting duration, diabetes, duration of GLP-1 RA use
- Not significantly associated with RGC
Original publication
Preoperative fasting status and retained gastric contents in patients undergoing endoscopy who are using glucagon-like peptide type 1 receptor agonists: a multicentre retrospective study. Can J Anaesth. Published 19 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →