Perioperative medicine & outcomes
Ultrasound assessment of preoperative gastric volume in fasted diabetic surgical patients: A prospective observational cohort study on the effects of glucagon-like peptide-1 agonists on gastric emptying
Authors' conclusion
GLP-1 agonist therapy was associated with higher residual gastric volumes and higher risks of full stomachs in fasted diabetic patients.
Study context
- Population
- Appropriately fasted diabetic patients undergoing elective surgery
- Participants
- 106 vs 100
- Exposure
- GLP-1 agonist use vs no GLP-1 agonist use
- GLP-1 agonistsn = 106
- Not taking GLP-1 agonistsn = 100reference
- Outcome
- Gastric volume by gastric ultrasound in the right lateral decubitus position
Main finding
As reported in the abstract
Gastric volume
P < 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (95 % CI) | P value | |
|---|---|---|---|
| Full stomach (solids/thick liquids or >1.5 mL/kg clear liquid) | 11.3 (5.2–24.7) | P < 0.0001 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | P value |
|---|---|
| Perlas grade | P < 0.001 |
Perlas grade
- GLP-1 agonist use correlated with higher Perlas grades
Gastric volume by timing of last GLP-1 agonist dose (subgroup)
- Significantly higher gastric volumes with use within 7 days of surgery vs use within 7-14 days or >14 days from surgery
- P < 0.001 for both comparisons
Original publication
Ultrasound assessment of preoperative gastric volume in fasted diabetic surgical patients: A prospective observational cohort study on the effects of glucagon-like peptide-1 agonists on gastric emptying. J Clin Anesth. Published 4 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →