Association between glucagon‐like peptide‐1 receptor agonist use and peri‐operative pulmonary aspiration: a systematic review and meta‐analysis
Pooled result · Pulmonary aspirationResult — go to the resultOdds ratio 1.04 95% CI 0.87–1.25Authors' conclusion
Patients using glucagon-like peptide-1 receptor agonists are at increased risk of presenting for anaesthesia with residual gastric contents, though the available evidence does not indicate that this translates to an increased risk of pulmonary aspiration.
Study context
- Population
- Fasted patients or volunteers undergoing procedures requiring anaesthesia or sedation28 observational studies
- Comparison
- GLP-1 receptor agonist exposure vs no exposure
- Outcome
- Peri-operative pulmonary aspiration
Methodological detailsrandom effects meta-analysis, GRADE certainty assessment, Six databases searched; 9010 studies screened
- Random effects meta-analysis
- GRADE certainty assessment
- Six databases searched; 9010 studies screened
Pooled result
Pulmonary aspiration
Odds ratio
1.04
95% CI 0.87–1.25
GLP-1 receptor agonist vs No GLP-1 receptor agonist
OR 1.04 (95% CI 0.87–1.25)
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| Residual gastric contents despite appropriate fastingGLP-1 receptor agonist vs No GLP-1 receptor agonist · 18 studies, 165,522 patients, 3831 cases · low certainty of evidence | 5.96 (3.96–8.98) | |
| 0.10.31310Odds ratio (log scale) |
Residual gastric contents: withholding ≥1 dose before procedure vs not withholding
| OR (95% CI) | ||
|---|---|---|
| Withholding at least one dose5 studies, 1706 patients, 208 cases · very low certainty of evidence | 0.51 (0.33–0.81) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Association between glucagon‐like peptide‐1 receptor agonist use and peri‐operative pulmonary aspiration: a systematic review and meta‐analysis. Anaesthesia. Published 15 April 2025. doi:10.
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