Peri‐operative glucagon‐like peptide‐1 receptor agonist use and outcomes: a national prospective multicentre cohort study
Authors' conclusion
In this national study, 1 in 36 patients undergoing anaesthesia care received GLP-1 RAs, and their peri-operative management was variable.
Study context
- Population
- Adults undergoing elective or emergency procedures under the care of an anaesthetist, UK
- Participants
- 47,039 adults · 119 UK sites
- Exposure
- GLP-1 RA use vs no GLP-1 RA use in the 3 months before the procedure
- GLP-1 RAn = 1,348
- Non-GLP-1 RAn = 45,691reference
- Outcome
- Proportion of patients receiving GLP-1 RAs
Methodological detailsnational, multicentre
- National
- Multicentre
Main finding
As reported in the abstract
Proportion receiving GLP-1 RAs
GLP-1 RA
2.9%
1348
Observational data: associations, not effects.
Secondary outcomes
Peri-operative management of GLP-1 RA patients
- Variable regarding drug cessation, anaesthesia and airway management
Safety
| Outcome | GLP-1 RA | Non-GLP-1 RA | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Pulmonary aspiration and/or regurgitation | 1.41% (95% CI 0.85–2.19%) | 0.12% (95% CI 0.09–0.16%) | 11.39 (6.47–20.05) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
Pulmonary aspiration and/or regurgitation
- In GLP-1 RA patients, occurred most frequently during emergence from anaesthesia
Original publication
Peri‐operative glucagon‐like peptide‐1 receptor agonist use and outcomes: a national prospective multicentre cohort study. Anaesthesia. Published 16 September 2026. doi:10.
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