Association between preoperative obstructive sleep apnea diagnosis and prolonged postoperative opioid use among patients undergoing common surgical procedures
Main finding · Adjusted incidence of prolonged postoperative opioid useResult — go to the resultDifference 0.0% 95% CI −0.1 to 0.0Authors' conclusion
A preoperative OSA diagnosis was not associated with a change in the risk of prolonged postoperative opioid use across common surgical procedures
Study context
- Population
- Opioid-naïve patients undergoing 11 common surgeries, MarketScan Commercial and Medicare Claims Databases, 2016–2021
- Participants
- 270,320 patients
- Exposure
- Preoperative obstructive sleep apnea (OSA) diagnosis vs no OSA
- OSAn = 29,095
- Outcome
- Prolonged postoperative opioid use (≥10 prescriptions or ≥120 days' supply of opioids)
- Follow-up
- POD 91-365
Methodological detailsadministrative claims data, multivariable logistic regression
- Administrative claims data
- Multivariable logistic regression
Main finding
As reported in the abstract
Adjusted incidence of prolonged postoperative opioid use
Difference
0.0%
95% CI −0.1 to 0.0
P = 0.184
By group
OSA vs Without OSA
difference 0.0% (95% CI −0.1 to 0.0); P = 0.184
Observational data: associations, not effects.
Further findings
- Unadjusted incidence of prolonged postoperative opioid use — OSA
- 0.6% (95% CI 0.5–0.7)
Sensitivity analyses (alternate outcome, exposure, cohort)
- Results robust to alternate specifications of outcome, exposure, and cohort
Original publication
Association between preoperative obstructive sleep apnea diagnosis and prolonged postoperative opioid use among patients undergoing common surgical procedures. Reg Anesth Pain Med. Published 24 August 2025. doi:10.
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