Hemodynamics, fluids & transfusion
Association between red blood cell transfusion and adverse clinical outcomes is Independent of cardiac history: a multicenter observational InPUT study analysis
Primary result · Composite outcome per additional RBC unit, whole cohortResult — go to the resultodds 2.18 95% CI 1.85–2.56Authors' conclusion
RBC transfusion was commonly and similarly prescribed in critically ill patients with or without cardiac history. Each additional unit was associated with a worse outcome with no evidence of differential effect due to cardiac history.
Study context
- Population
- Critically ill ICU patients in the International Point-Prevalence Study of ICU Transfusion Practices cohort894 transfused ≥1 red-blood-cell (RBC) unit
- Participants
- 3,643 patients
- Comparison
- Number of RBC units transfused; interaction with cardiac history
- Cardiac historyn = 746
- Primary endpoint
- Composite of:
- 28-day mortality
- New-onset AKI
- Ventilatory weaning failure
Methodological detailspoint-prevalence cohort, weighted logistic regression
- Point-prevalence cohort
- Weighted logistic regression
Primary result
As reported in the abstract
Composite outcome per additional RBC unit, whole cohort
odds
2.18
95% CI 1.85–2.56
P < 0.0001
- No interaction with cardiac history
- P = 0.44
Further findings
Transfusion rate
P = 0.51
Nadir haemoglobin during ICU stay (transfused patients)
P = 0.007
Stated haemoglobin transfusion threshold (transfused patients)
P = 0.11
Original publication
Association between red blood cell transfusion and adverse clinical outcomes is Independent of cardiac history: a multicenter observational InPUT study analysis. Crit Care. Published 18 December 2025. doi:10.
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