ICU sedation, delirium & recovery
Association Between Sex and Clinical Outcomes for Critically Ill Patients in India: A Registry-Embedded Cohort Study
Main finding · ICU mortalityResult — go to the resultAdjusted odds ratio 0.95 95% CI 0.90–1.00Authors' conclusion
In this registry-embedded cohort study, critically ill females less commonly received most types of organ supports, yet had similar adjusted ICU mortality compared with males.
Study context
- Population
- Adult (≥ 16 yr) patients admitted to 45 ICUs in the Indian Registry of IntenSive care (IRIS)
- Participants
- 82,151 participants · 45 ICUs
- Exposure
- Females vs males
- Femalesn = 31,409
- Outcome
- ICU mortality
Methodological detailsmulticentre registry, adjusted for prespecified baseline covariates
- Multicentre registry
- Adjusted for prespecified baseline covariates
Main finding
As reported in the abstract
Adjusted odds ratio
0.95
95% CI 0.90–1.00
P = 0.07
By group
Females vs Males
aOR 0.95 (95% CI 0.90–1.00); P = 0.07
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Females | Males | Estimate | P value | |
|---|---|---|---|---|---|
| Hospital mortality | 19.4% | 20.8% | aOR 1.00 (95% CI 0.97–1.03) | P = 0.66 | |
| Invasive ventilation | 22.2% | 26.3% | aOR 0.78 (95% CI 0.75–0.82) | P < 0.001 | |
| Kidney replacement therapy | 4.9% | 6.3% | aOR 0.73 (95% CI 0.68–0.78) | P < 0.001 | |
| Vasopressors | 19.1% | 20.2% | aOR 0.95 (95% CI 0.92–0.99) | P = 0.03 | |
| NIV | 11.7% | 9.7% | OR 1.23 (95% CI 1.18–1.30) | P < 0.001 | |
| 0.512Ratio (log scale) |
Sensitivity analyses
- Consistent with the primary findings
Original publication
Association Between Sex and Clinical Outcomes for Critically Ill Patients in India: A Registry-Embedded Cohort Study. Crit Care Med. Published 14 May 2026. doi:10.
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