ICU sedation, delirium & recovery
Persistent Critical Illness Among Intensive Care Patients in India: A Registry-Embedded Cohort Study
Authors' conclusion
In this cohort of critically ill patients in India, as ICU stay increased, the prognostic performance of acute illness characteristics decreased whereas that of antecedent characteristics remained poor.
Study context
- Population
- Adult critically ill patients in 56 ICUs of the Indian Registry of Intensive Care
- Participants
- 42,925 patients · 56 ICUs
- Exposure
- Acute illness vs antecedent characteristics for prognosis of hospital mortality; ICU stay >7 days vs ≤7 days (post hoc)
- Outcome
- Hospital mortality
Methodological detailsmulticentre registry, post hoc analyses, Generalized mixed-effects models
- Multicentre registry
- Post hoc analyses
- Generalized mixed-effects models
Main finding
As reported in the abstract
Prognostic performance for hospital mortality (AUROC)
| Group | AUROC at admission | AUROC at day 7 |
|---|---|---|
| Acute illness characteristics | 0.76 | 0.69 |
| Antecedent characteristics | 0.56 | 0.56 |
AUROC at admission
Acute illness characteristics0.76
Antecedent characteristics0.56
AUROC at day 7
Acute illness characteristics0.69
Antecedent characteristics0.56
- Hospital mortality, whole cohort
- 17.4%
Observational data: associations, not effects.
Further findings
| Outcome | ICU stay >7 days | ICU stay ≤7 days | OR (95% CI) | |
|---|---|---|---|---|
| Hospital mortality, ICU stay >7 days vs ≤7 days (post hoc)Post hoc | 33.1% | 14.6% | 2.17 (2.03–2.31) | |
| 0.512Odds ratio (log scale) |
ICU mortality, ICU stay >7 days vs ≤7 days (post hoc) · post hoc
Median
| Outcome | ICU stay >7 days | ICU stay ≤7 days | P value |
|---|---|---|---|
| APACHE II, ICU stay >7 days vs ≤7 days (post hoc)Post hoc | 14 (IQR 9–19) | 10 (IQR 6–15) | P < 0.001 |
Organ support, ICU stay >7 days vs ≤7 days (post hoc)
- Invasive ventilation, >7 days vs ≤7 days
- 51.7% vs. 19.5%
- NIV, >7 days vs ≤7 days
- 18.4% vs. 7.6%
- Vasopressors, >7 days vs ≤7 days
- 34.7% vs. 19.1%
- Kidney replacement therapy, >7 days vs ≤7 days
- 11.4% vs. 6.1%
- All significantly higher with ICU stay >7 days
- Post hoc
Original publication
Persistent Critical Illness Among Intensive Care Patients in India: A Registry-Embedded Cohort Study. Crit Care Med. Published 16 June 2025. doi:10.
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