ICU sedation, delirium & recovery
Timing of Onset of Persistent Critical Illness in Brazil: A Nested Secondary Analysis of the IMPACTO-MR Cohort Study
Authors' conclusion
In Brazilian ICUs, the transition to PerCI occurs at 15 days, later than that reported in most prior studies. Although only one in ten patients develop PerCI, they use almost half of ICU bed-days.
Study context
- Population
- Adults admitted to 56 ICUs of the IMPACTO-MR platform, public and private hospitals in Brazil, September 2019 to December 2023
- Participants
- 75,475 adults · 56 ICUs
- Comparison
- Acute illness model vs Antecedent characteristics model
Methodological detailsmulticentre, nested, training and test cohorts
- Multicentre
- Nested
- Training and test cohorts
Primary result
As reported in the abstract
Discrimination for in-hospital mortality; onset of PerCI
| Group | AUROC at admission |
|---|---|
| Acute illness model | 0.828 |
| Antecedent characteristics model | 0.638 |
AUROC at admission
Acute illness model0.828
Antecedent characteristics model0.638
Further findings
Patients meeting persistent critical illness (PerCI) definition and ICU bed-days used
- Patients with PerCI
- 7960 (10.5%)
- Share of all ICU bed-days used by PerCI patients
- 44.2%
Mortality in PerCI patients
- ICU mortality
- 38.2%
- In-hospital mortality
- 51.2%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Timing of Onset of Persistent Critical Illness in Brazil: A Nested Secondary Analysis of the IMPACTO-MR Cohort Study. Crit Care Med. Published 21 May 2026. doi:10.
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