Respiratory failure & ventilation
Integrated Telehealth Rehabilitation and Quality of Life in Mechanically Ventilated Adults: A Randomized Clinical Trial
Primary result · EQ-5D-3L utility scoreResult — go to the resultAdjusted difference 0.049 95% CI 0.0002–0.098Authors' conclusion
In this study, an integrated telehealth-based rehabilitation strategy delivered across ICU, hospital, and postdischarge phases improved 90-day health-related quality of life, potentially influenced by reduced mortality.
Study context
- Population
- Adults with acute hypoxemic respiratory failure requiring invasive mechanical ventilation, intensive care unit (ICUs) of 20 public hospitals in Brazil
- Participants
- 1,916 adults · 20 hospitals
- Comparison
- Integrated multicomponent telehealth-based rehabilitation vs usual care
- Interventionn = 1,063
- Usual caren = 853reference
- Primary endpoint
- Health-related quality of life (EQ-5D-3L utility score, range −0.17 [worse than death] to 1 [best health state], 0 = death)
- Follow-up
- 90 days after hospital discharge
Methodological detailsmulticentre
- Multicentre
Primary result
EQ-5D-3L utility score
Adjusted difference
0.049
95% CI 0.0002–0.098
P = 0.04
By group
Intervention
0.16
mean · SD 0.31
Usual care
0.12
mean · SD 0.28
Intervention vs Usual care
adjusted difference 0.049 (95% CI 0.0002–0.098); P = 0.04
As reported in the abstract
Further findings
| Outcome | Intervention | Usual care | Adjusted difference (95% CI) | P value | |
|---|---|---|---|---|---|
| EQ-5D-3L utility score among survivors (subgroup) · 90 days after hospital dischargeMean | 0.60 (SD 0.32) | 0.59 (SD 0.32) | −0.045 (−0.138 to 0.045) | P = 0.34 | |
| All-cause mortality · 90 days | 71.8% | 78.3% | −7.6% (−14.7% to −0.6%) | P = 0.03 | |
| −20−10010Difference (linear scale) |
Mean, days
| Outcome | Intervention | Usual care | Adjusted difference (days) (95% CI) | P value | |
|---|---|---|---|---|---|
| Mechanical ventilation duration | 9.9 (SD 10.3) | 15.5 (SD 15.9) | −6.2 (−8.5 to −3.9) | P < 0.001 | |
| −10−505Difference, days (linear scale) |
- All-cause mortality: 676 of 941 vs 584 of 746
Original publication
Integrated Telehealth Rehabilitation and Quality of Life in Mechanically Ventilated Adults: A Randomized Clinical Trial. JAMA. Published 15 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →