Respiratory failure & ventilation
Multicomponent Pulmonary Rehabilitation for Prolonged Mechanical Ventilation in Patients Aged 80 Years or Older: A Randomized Controlled Trial
Primary result · Successful weaningResult — go to the resultAdjusted hazard ratio 5.11 95% CI 2.46–11.23Authors' conclusion
In patients aged ≥80 years receiving prolonged mechanical ventilation, the multicomponent pulmonary rehabilitation program improved physiological recovery and significantly increased successful weaning.
Study context
- Population
- Patients aged ≥80 years receiving prolonged mechanical ventilation, Chinese PLA General HospitalITT analysis
- Participants
- 75 vs 75
- Comparison
- Multicomponent pulmonary rehabilitation vs standard rehabilitation
- Multicomponent pulmonary rehabilitationn = 75
- Standard rehabilitationn = 75reference
- Primary endpoint
- Successful weaning
Methodological detailssingle-centre, assessor-blinded
- Single-centre
- Assessor-blinded
Primary result
As reported in the abstract
Adjusted hazard ratio
5.11
95% CI 2.46–11.23
P < 0.001
By group
Secondary outcomes
Successful weaning, Fine-Gray competing-risk analysis (sensitivity analysis)
- sHR
- 4.45 (95% CI, 2.11-9.36; P < 0.001)
Oxygen saturation, diaphragm thickening fraction, cough strength, muscle strength · 30, 60, and 90 days
- Higher odds of meeting prespecified improvement criteria in the intervention group
Ventilator-associated pneumonia (VAP) incidence · days 60 and 90
- Lower VAP incidence in the intervention group
All-cause mortality · 90 days
- Trial group
- 2.7% (2/75)
- Control group
- 4.0% (3/75)
- Between-group P
- P = 1.000
Per-protocol analysis
- Similar results
Safety
Deep vein thrombosis (DVT) · day 90 or end of participation
- No significant difference between the two groups
Original publication
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