Respiratory failure & ventilation
Effectiveness of a standardized weaning protocol in tracheostomized patients with prolonged mechanical ventilation: a prospective single-arm interventional trial
Authors' conclusion
A standardized weaning protocol delivered in a dedicated rehabilitation unit was associated with a 60-day weaning success rate that exceeded a pre-specified historical benchmark in PMV patients.
Study context
- Population
- Consecutive tracheostomized patients with prolonged mechanical ventilation (PMV) at a specialized weaning unit of a tertiary rehabilitation hospital, January–October 2025
- Participants
- 250 participants
- Exposure
- Weaning protocol vs Historical benchmark
- Weaning protocoln = 250
- Outcome
- Weaning success rate
- Follow-up
- 60 days
Methodological detailssingle-centre, historical benchmark comparison
- Single-centre
- Historical benchmark comparison
Main finding
As reported in the abstract
60-day weaning success rate
Weaning success, n/N
189 of 250
Weaning success rate
75.6%
95% CI 69.9–80.5%
RR vs historical benchmark (p₀ = 65%)
1.16
95% CI 1.08–1.25; p < 0.001
Observational data: associations, not effects.
Secondary outcomes
Weaning duration
- Mean weaning duration (± 10.0 days)
- 19.9 days
30-day reconnection among successfully weaned patients
- 30-day reconnection
- 2.1%
6-month mortality
- Overall 6-month mortality
- 14.4%
- Successfully weaned
- 9.0%
- Not successfully weaned
- 31.1%
- Confounding and limited event numbers precluding a definitive causal inference
Weaning success by calculated weaning score tertile (subgroup)
- T1
- 44.0%
- T2
- 84.3%
- T3
- 98.8%
- Trend
- P < 0.001
- Monotonic gradient
Original publication
Effectiveness of a standardized weaning protocol in tracheostomized patients with prolonged mechanical ventilation: a prospective single-arm interventional trial. J Intensive Care. Published 2 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →