Effects of direct tracheostomy on ventilator weaning in patients intubated for Guillain-Barré syndrome
Authors' conclusion
A direct tracheostomy without any prior weaning attempt might significantly delay the ventilator weaning process in patients intubated for GBS.
Study context
- Population
- Patients intubated for Guillain-Barré syndrome (GBS), 2014–2023
- Participants
- 221 vs 273
- Exposure
- Direct tracheostomy without prior weaning attempt vs standard weaning
- Direct tracheostomyn = 221
- Standard weaningn = 273reference
- Outcome
- Proportion alive and free from mechanical ventilation
- Follow-up
- 28 days after weaning initiation
Methodological detailsmulticentre, G-computation
- Multicentre
- G-computation
Main finding
As reported in the abstract
day 28
Marginal causal effect on risk of remaining under mechanical ventilation (G-computation)
−39.5%
95% CI −47.3% to −31.5%
By group
Standard weaning vs Direct tracheostomy
marginal causal effect on risk of remaining under mechanical ventilation (G-computation) −39.5% (95% CI −47.3% to −31.5%)
Observational data: associations, not effects.
Further findings
Alive and free from mechanical ventilation, direct tracheostomy vs tracheostomy after weaning failure · 28 days after the tracheostomy procedure
- Direct tracheostomy less likely to be alive and free from mechanical ventilation than tracheostomy after weaning failure
Original publication
Effects of direct tracheostomy on ventilator weaning in patients intubated for Guillain-Barré syndrome. Ann Intensive Care. Published 28 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →