Respiratory failure & ventilation
Characteristics of ventilator weaning in patients intubated for Guillain–Barré syndrome or myasthenia gravis: a nationwide multicenter study
Authors' conclusion
Patients with GBS were more likely to experience prolonged weaning and to undergo tracheostomy than patients with MG. More than one-fourth of patients required reintubation after an extubation attempt. Despite prolonged duration of mechanical ventilation, mortality remained relatively low.
Study context
- Population
- Patients intubated for at least 48 h for Guillain-Barré syndrome (GBS) or myasthenia gravis (MG), 47 ICUs in France, January 2014 to December 2023
- Participants
- 886 patients · 47 ICUs
- Exposure
- GBS vs MG
- GBSn = 513
- MGn = 373reference
- Outcome
- Proportion of patients with prolonged weaning (at least 7 days)
Methodological detailsmulticentre, nationwide
- Multicentre
- Nationwide
Main finding
As reported in the abstract
Prolonged weaning
P < 0.001
Observational data: associations, not effects.
Further findings
Extubation attempt performed
P < 0.001
Reintubation
P = 0.440
Tracheostomy
P < 0.001
Mortality
P = 0.882
Duration of mechanical ventilation and ICU stay
- Longer in GBS than MG
Original publication
Characteristics of ventilator weaning in patients intubated for Guillain–Barré syndrome or myasthenia gravis: a nationwide multicenter study. Intensive Care Med. Published 20 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →