Survival after ICU discharge is shaped more by chronic disease than admission severity

Blet, A; Walter-Petrich, A; Chérifa, M; Bruno, J; Tran Dinh, A; Azoulay, E; Chousterman, B; Cotter, G; Davison, B; Deniau, B; Gayat, E; Guidet, B; Harrois, A; Kimmoun, A; Leone, M; Wittebole, X; Ambrosy, AP; Mebazaa, A; Resche-Rigon, M

doi:10.1016/j.jcrc.2025.155401

ICU sedation, delirium & recovery

Survival after intensive care unit (ICU) discharge is shaped more by chronic disease than admission severity

J Crit CarePublished 10 Dec 2025Post-hoc analysis of the FROG-ICU prospective observational cohort

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Authors' conclusion

In this analysis, pre-existing chronic conditions were primary drivers of short- and long-term survival after ICU discharge, exceeding prognostic value of acute illness severity at admission.

Study context

Population: ICU survivors from 21 French ICUs with complete data on admission severity scores, comorbidities and cardiovascular/renal biomarkers at dischargeof 1548 ICU survivors
Participants: 1,400 survivors

Comparison: Chronic comorbidity (CCI) vs admission severity scores (SAPS-II, SOFA) and discharge biomarkers for predicting mortality after ICU discharge
Primary endpoint: One-year mortality (Cox models; discrimination by time-dependent AUC)
Follow-up: One year

Methodological detailsmulticentre

Multicentre

Primary result

As reported in the abstract

Discrimination for mortality (time-dependent AUC)

Group	AUC day 7	AUC 3 weeks	AUC
CCI	0.70 (95% CI 0.64-0.77)	0.75 (0.69-0.78)	— not stated in the abstract
SAPS-II	— not stated in the abstract	— not stated in the abstract	0.63 (0.54-0.72)
SOFA	— not stated in the abstract	— not stated in the abstract	0.61 (0.53-0.68)

AUC day 7

CCI0.70 (95% CI 0.64-0.77)

SAPS-II—

SOFA—

AUC 3 weeks

CCI0.75 (0.69-0.78)

SAPS-II—

SOFA—

AUC

CCI—

SAPS-II0.63 (0.54-0.72)

SOFA0.61 (0.53-0.68)

— not stated in the abstract

Further findings

Cardiovascular (NT-proBNP, bio-ADM) and kidney (pNGAL) biomarkers

Comparable short-term discriminatory value; CCI better for long-term outcomes across admission diagnoses

Original publication

Survival after ICU discharge is shaped more by chronic disease than admission severity. J Crit Care. Published 10 December 2025. doi:10.1016/j.jcrc.2025.155401

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