Association between serum uric acid level and outcome in intensive care unit, an ancillary analysis of the FROG-ICU cohort (URIC-ICU)
Primary result · 90-day mortalityResult — go to the resultOdds ratio 1.43 95% CI 1.11–1.82Authors' conclusion
Patients admitted to the ICU displayed a low level of SUA compared to the general population. Higher SUA level was associated with increased 90-day mortality, increased incidence of AKI, even among patients without altered GFR on admission, suggesting a possible role of uric acid in the worsening of renal function.
Study context
- Population
- ICU patients with serum uric acid (SUA) measurement at inclusion, FROG-ICU cohort
- Participants
- 1,741 patients
- Comparison
- Higher SUA at admission vs lower SUA
- Primary endpoint
- 90-day mortality
- Follow-up
- 90 days
Methodological detailsancillary study, propensity-score matched analysis, subgroup analysis
- Ancillary study
- Propensity-score matched analysis
- Subgroup analysis
Primary result
As reported in the abstract
Odds ratio
1.43
95% CI 1.11–1.82
Higher SUA vs Lower SUA
OR 1.43 (95% CI 1.11–1.82)
Secondary outcomes
1-year mortality, acute kidney injury (AKI) occurrence, MAKE at day 30
- Higher SUA significantly associated with every secondary endpoint
AKI and mortality (subgroup with unaltered glomerular filtration rate (GFR) at admission)
- Association between SUA and AKI and mortality also significant
Baseline SUA and SOFA · admission
- Median SUA (µmol/L) [113-273]
- 175
- Median SOFA score [5-10]
- 7
Original publication
Association between serum uric acid level and outcome in intensive care unit, an ancillary analysis of the FROG-ICU cohort (URIC-ICU). Anaesth Crit Care Pain Med. Published 29 September 2025. doi:10.
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