Acute kidney injury detection with additional point-of-care creatinine vs central laboratory serum creatinine measurement in critically ill patients
Main finding · Individual difference in time to AKI diagnosis, CrP vs CrCResult — go to the resultMedian difference −5 hAuthors' conclusion
Combined with CrC, CrP measurement resulted in the earlier diagnosis of AKI during ICU admission. Compared to CrC alone, using CrP measurements in combination with CrC was also associated with a higher maximum AKI stage and more detection of worsening AKI.
Study context
- Population
- Critically ill patients with two or more CrP measurements 24 h before an acute kidney injury (AKI) was diagnosed on CrC
- Participants
- 1,591 patients
- Exposure
- CrC + CrP vs CrC
- Outcome
- Time to AKI diagnosis (earlier and more frequent AKI diagnosis)
Methodological detailsMedian APACHE 3 score 67 (IQR 52-85); median number of CrP measurements 5 (IQR 3-6)
- Median APACHE 3 score 67 (IQR 52-85); median number of CrP measurements 5 (IQR 3-6)
Main finding
As reported in the abstract
Individual difference in time to AKI diagnosis, CrP vs CrC
Median difference
−5 h
Observational data: associations, not effects.
Further findings
Detected increases in AKI severity, stage 1
Detected increases in AKI severity, stage 2
Detected increases in AKI severity, stage 3
- Detected increases in AKI severity, stage 1: p < 0.001 across stages
- Detected increases in AKI severity, stage 2: p < 0.001 across stages
- Detected increases in AKI severity, stage 3: p < 0.001 across stages
Difference in time to AKI diagnosis by number of CrP tests in the 24 h before CrC-defined AKI
- Difference in hours increased as number of point-of-care tests increased, from −3 (IQR −6--1) to −8 (IQR −13- −2)
- P < 0.001
Original publication
Acute kidney injury detection with additional point-of-care creatinine vs central laboratory serum creatinine measurement in critically ill patients. J Crit Care. Published 6 March 2025. doi:10.
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