Biomarkers in acute kidney injury settings to predict interventions and outcomes: the MARKISIO study
Authors' conclusion
Neither routine nor novel biomarkers demonstrated conclusive predictive accuracy for the need for RRT in severe AKI patients.
Study context
- Population
- Severe acute kidney injury (AKI) (stage 3) patients receiving invasive mechanical ventilation and/or vasopressors
- Participants
- 256 participants
- Comparison
- Routine and novel serum and urinary biomarkers for predicting renal replacement therapy (RRT) initiation criteria
- Primary endpoint
- Onset of precise criteria for RRT initiation
- Follow-up
- Within 72 h after severe AKI
Methodological detailsprognostic biomarker study, Blood and urine samples collected within 12 h after severe AKI when feasible
- Prognostic biomarker study
- Blood and urine samples collected within 12 h after severe AKI when feasible
Primary result
As reported in the abstract
Criteria for RRT initiation within 72 h · 72 h
Met at least one criterion for RRT initiation or died within 72 h
101
39%
Further findings
- No novel biomarker significantly associated with MAKE60
- SAPSIII and serum potassium at D0 significantly associated with MAKE60 (multivariable analysis)
Original publication
Biomarkers in acute kidney injury settings to predict interventions and outcomes: the MARKISIO study. Crit Care. Published 20 May 2025. doi:10.
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