Predicting the Development of Renal Replacement Therapy Indications by Combining the Furosemide Stress Test and Chemokine (C-C Motif) Ligand 14 in a Cohort of Postsurgical Patients
Authors' conclusion
The combination of the FST with the renal biomarker CCL14 predicts the development of indications for RRT.
Study context
- Population
- Critically ill postoperative patients with moderate acute kidney injury (AKI) (KDIGO stage 2) and risk factors for progression (vasopressors and/or mechanical ventilation) receiving an furosemide stress test (FST), University Hospital of Muenster, Germany108 FST negative
- Participants
- 208 patients
- Exposure
- FST + CCL14 vs FST vs CCL14
- Outcome
- Development of ≥1 predefined RRT indication (hyperkalemia ≥ 6 mmol/L, diuretic-resistant hypervolemia, urea ≥ 150 mg/dL, pH ≤ 7.15, oliguria < 200 mL/12 hr, or anuria)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Prediction of the primary endpoint at inclusion · At the time of inclusion
| Group | AUC |
|---|---|
| FST + CCL14 | 0.87 (95% CI, 0.82-0.92) |
| FST | 0.79 (95% CI, 0.74-0.85) |
| CCL14 | 0.83 (95% CI, 0.77-0.89) |
AUC
FST + CCL140.87 (95% CI, 0.82-0.92)
FST0.79 (95% CI, 0.74-0.85)
CCL140.83 (95% CI, 0.77-0.89)
- FST + CCL14 vs FST or CCL14 alone: P < 0.001 — significantly higher predictive value for the combination
Observational data: associations, not effects.
Further findings
Incidence of the primary endpoint
- Met the primary endpoint, overall
- 98 (47%)
- Met the primary endpoint, FST negative cohort
- 82%
Other biomarkers (NGAL, dipeptidyl peptidase 3)
- Other biomarkers showed lower AUCs
Original publication
Predicting the Development of Renal Replacement Therapy Indications by Combining the Furosemide Stress Test and Chemokine (C-C Motif) Ligand 14 in a Cohort of Postsurgical Patients. Crit Care Med. Published 29 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →