Association Between Surgical Opioid Prescriptions and Opioid Initiation by Opioid-naïve Spouses
Main findingResult — go to the resultAdjusted odds ratio 1.37 95% CI 1.31–1.43Authors' conclusion
Surgical opioid prescriptions were associated with increased risk of opioid initiation by spouses of operative patients, suggesting that risks associated with surgical opioids may extend beyond the surgical patient.
Study context
- Population
- Opioid-naïve, married patients undergoing 1 of 11 common surgeries, January 1, 2011 to June 30, 2017
- Participants
- 318,022 participants
- Exposure
- Surgical opioid prescription filled vs not filled
- Filled surgical opioid prescriptionn = 267,189
- No surgical opioid prescriptionn = 50,833reference
- Outcome
- Opioid initiation by the operative patient's spouse
- Follow-up
- 6-months after surgery
Main finding
As reported in the abstract
Adjusted odds ratio
1.37
95% CI 1.31–1.43
P < 0.001
Events by group
Filled surgical opioid prescription vs No surgical opioid prescription
aOR 1.37 (95% CI 1.31–1.43); P < 0.001
Observational data: associations, not effects.
Further findings
Spouse opioid initiation, postoperative month 1
- Associated risk only mildly elevated
- aOR 1.11, 95% CI 1.00-1.23, P = 0.04
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association Between Surgical Opioid Prescriptions and Opioid Initiation by Opioid-naïve Spouses. Ann Surg. Published 23 December 2021. doi:10.
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