High-risk Opioid Prescribing Associated with Postoperative New Persistent Opioid Use in Adolescents and Young Adults
Main finding · Persistent opioid useResult — go to the resultAdjusted odds ratio 1.235 CI 1.12,1.36Authors' conclusion
High-risk opioid prescribing practices, particularly receiving prescriptions from multiple prescribers across specialties, were associated with a significant increase in adolescent and young adult patients' risk of persistent opioid use.
Study context
- Population
- Opioid-naïve patients aged 13 to 21 who underwent 1 of 13 procedures (2008–2016) and filled a perioperative opioid prescription
- Exposure
- High-risk opioid prescribing vs no high-risk prescribing
- Outcome
- Persistent opioid use (≥ 1 opioid prescription fill 91 to 180 days after surgery)
- Follow-up
- 91 to 180 days after surgery
Methodological detailscommercial insurance claims database
- Commercial insurance claims database
Main finding
Persistent opioid use
Adjusted odds ratio
1.235
CI 1.12,1.36
High-risk prescribing vs No high-risk prescribing
aOR 1.235 (CI 1.12,1.36)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Persistent opioid use, multiple opioid prescribers
| aOR (CI) | ||
|---|---|---|
| Multiple prescribers | 1.288 (1.16,1.44) | |
| 0.512Adjusted odds ratio (log scale) |
Trend in high-risk opioid prescribing over study period
- Co-prescribed benzodiazepines increased (largest increase)
- 24.1%-33.4%
- High-risk prescribing increased from 34.9% to 43.5%
Prescriptions from nonsurgical prescribers among persistent users beyond the postoperative period
- Majority of opioid prescriptions from nonsurgical prescribers
- 79.6%
Original publication
High-risk Opioid Prescribing Associated with Postoperative New Persistent Opioid Use in Adolescents and Young Adults. Ann Surg. Published 27 August 2021. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →