Postoperative Opioid Prescribing and New Persistent Opioid Use: The Risk of Excessive Prescribing
Main finding · New persistent opioid useResult — go to the resultAdjusted odds ratio 0.88 95% CI 0.71–1.09Authors' conclusion
In a cohort of opioid-naïve patients undergoing common surgical procedures, the risk of new persistent opioid use increased with the size of the prescription.
Study context
- Population
- Opioid-naïve adults undergoing surgery in Michigan, 1/1/2017 to 10/31/2019
- Participants
- 37,654 adults
- Exposure
- Prescribed opioid vs No opioid
- Prescribed opioidn = 31,920
- Outcome
- New persistent opioid use (≥1 opioid fill post-discharge days 4–90 and ≥1 fill days 91–180)
Methodological detailsstatewide clinical registry, prescription drug monitoring program
- Statewide clinical registry
- Prescription drug monitoring program
Main finding
New persistent opioid use
Adjusted odds ratio
0.88
95% CI 0.71–1.09
Prescribed opioid vs No opioid
aOR 0.88 (95% CI 0.71–1.09)
As reported in the abstract
- Patients developing new persistent opioid use, overall
- 622 (1.7%)
Observational data: associations, not effects.
Further findings
| Outcome | Smallest quartile | Second largest quartile | Largest quartile | aOR (95% CI) | |
|---|---|---|---|---|---|
| New persistent opioid use by prescription size quartile (among patients prescribed an opioid)Second largest quartile vs Smallest quartile · reference: smallest quartile | 7 (IQR 1) pills | 12 (IQR 3) pills | 20 (IQR 7) pills | 1.39 (1.04–1.86) | |
| 0.512Adjusted odds ratio (log scale) |
| Outcome | aOR |
|---|---|
| New persistent opioid use by prescription size quartile (among patients prescribed an opioid)Largest quartile vs Smallest quartile · CI garbled in the abstract · reference: smallest quartile | 1.97 |
Original publication
Postoperative Opioid Prescribing and New Persistent Opioid Use: The Risk of Excessive Prescribing. Ann Surg. Published 21 January 2022. doi:10.
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