Opioid consumption in the first 30 days after surgery was independently associated with new persistent opioid use
Authors' conclusion
Demonstrating that opioid consumption in the first 30 days after surgery was independently associated with NPOU underscores the importance of perioperative opioid prescribing on long-term outcomes.
Study context
- Population
- Opioid naïve individuals aged 18–64 undergoing surgery across 70 Michigan hospitals (July 1, 2018–November 15, 2021), prescribed opioids at discharge
- Participants
- 36,271 individuals
- Exposure
- Patient-reported opioid consumption in 30 days after discharge and new persistent opioid use (NPOU)
- NPOUn = 482
- Outcome
- New persistent opioid use (NPOU): opioid fill during both 31-120 days and 121-210 days after discharge
Methodological detailsmulticentre registry, linked to state Prescription Drug Monitoring Program, multivariable logistic regression
- Multicentre registry
- Linked to state Prescription Drug Monitoring Program
- Multivariable logistic regression
Main finding
As reported in the abstract
Predicted probability of NPOU per additional opioid pill consumed in 30-day postoperative period
Increase in predicted probability of NPOU per additional pill
0.05
percentage points; 95% CI 0.04 to 0.07
Increase in probability of NPOU per 10-pill increase (percentage points)
0.5
Relative increase vs baseline rate of 1.3% per 10-pill increase
38.4%
Observational data: associations, not effects.
Further findings
Opioid pills consumed in first 30 days postoperatively (5 mg oxycodone equivalent)
SMD −0.41
NPOU incidence
- Developed NPOU (482 patients)
- 1.3%
Original publication
Opioid consumption in the first 30 days after surgery was independently associated with new persistent opioid use. Reg Anesth Pain Med. Published 20 December 2024. doi:10.
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